Hussein, a Professor of Physics, was the 6th Substantive VC of the institution between 2005 and 2011.
He was 75.
Hussein died after a brief illness on Sunday evening.
The school announced his demise on its Twitter page @LASUOfficial on Monday
Prof. Hussain worked as a lecturer in the Department of Physics, University of Ibadan.
He was once the Chairman, University of Ibadan Muslim Community.